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Роль дейодиназ 1-го и 2-го типа в метаболизме тиреоидных гормонов (обзор литературы)

https://doi.org/10.14341/probl201662246-52

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Аннотация

Тиреоидные гормоны контролируют рост, развитие и обмен веществ организма. Дейодиназы йодтиронинов катализируют удаление остатка йода с внешнего или внутреннего кольца молекулы прогормона тироксина (Т4), продуцируя либо активную (Т3), либо неактивную (обратный Т3, оТ3) форму трийодтиронина. Дейодиназа 1-го типа (Д1) катализирует обе эти реакции. Дейодиназа 2-го типа (Д2) образует из Т4 активный Т3 внутри клетки, инициируя тем самым передачу гормонального сигнала на генетический аппарат клеток. Экспрессия Д2 в отдельных тканях (гипоталамус, гипофиз, бурая жировая ткань, улитка внутреннего уха, сетчатка глаза, кость и некоторые другие) свидетельствует о роли фермента в развитии этих органов. В обзоре описаны последние достижения в области изучения молекулярных свойств Д1 и Д2, а также их роли в физиологии.

Об авторе

Гульнора Мухамедовна Артыкбаева
Институт биоорганической химии им. aкад. А.С. Садыкова Академии наук Республики Узбекистан
Узбекистан
к.б.н., вед.н.с. лаб. молекулярной биологии клетки
Конфликт интересов: нет конфликта интересов


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Дополнительные файлы

1. Рис.1. Метаболизм основных йодотиронинов
Тема
Тип Прочее
Метаданные
2. Рис.2. Роль DIO2 в механизме обратной регуляции ГГТ оси
Тема
Тип Прочее
Посмотреть (10MB)    
Метаданные

Для цитирования:


Артыкбаева Г.М. Роль дейодиназ 1-го и 2-го типа в метаболизме тиреоидных гормонов (обзор литературы). Проблемы Эндокринологии. 2016;62(2):46-52. https://doi.org/10.14341/probl201662246-52

For citation:


Artykbaeva G.M. Role of type 1 and 2 deiodinases in thyroid metabolism (review). Problems of Endocrinology. 2016;62(2):46-52. (In Russ.) https://doi.org/10.14341/probl201662246-52

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