The age-specific peculiarities of hormonal and metabolic imbalance in the young and adult men with obesity
https://doi.org/10.14341/probl201561330-36
Abstract
The objective of the present study was to elucidate the peculiar features of hormonal and metabolic imbalance in the young and adult men depending on the time of obesity manifestation, that is in adolescence or in the mature age. It was shown that over 40% of the young and adult men with obesity developed the well-apparent testosterone deficiency regardless of the time of obesity manifestation (Me 11.2-11.7 nmol/l). The overwhelming majority of the patients showing testosterone deficiency (60-80%) made up subgroups with metabolic syndrome (MS). The young and adult men in whom obesity began to develop in adolescence exhibited a more pronounced increase of fasting blood insulin level and HOMA-IR index than the men who developed obesity in the adulthood. Only in both young and adult men who began to develop obesity in adolescence, the blood aldosterone and cortisol levels were higher than in the age-matched normal subjects. These men, unlike those with obesity starting to develop in the adulthood, had the blood aldosterone and cortisol levels shifted to the upper limit of the reference values
About the Authors
N P Goncharov
Endocrinology research Centre
G V Katsiya
Endocrinology research Centre
A F Verbovoy
Samara State Medical University
E V Mitroshina
Samara State Medical University
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Review
For citations:
Goncharov N.P., Katsiya G.V., Verbovoy A.F., Mitroshina E.V. The age-specific peculiarities of hormonal and metabolic imbalance in the young and adult men with obesity. Problems of Endocrinology. 2015;61(3):30-36. (In Russ.) https://doi.org/10.14341/probl201561330-36
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