Antibodies against NALP5 and it’s role in hypoparathyroidism in autoimmune polyglandular syndrome type 1
https://doi.org/10.14341/probl201662225-30
Abstract
Hypoparathyroidism is one of major components of autoimmune polyglandular syndrome type 1 (APS type 1) with a prevalence 73—83%. The protein NALP5 has been described previously as an antigen of parathyroid glands.
Aim — to investigate antibodies against NALP5 in patients with APS type 1.
Material and methods. Seventy nine patients with APS type 1 were included in the study. Radio-immune assay was used for detecting antibodies against NALP5.
Results. The correlation between hypoparathyroidism and high levels of antibodies against NALP5 was found (p<0.001). Sensitivity of the method was 69,4%, specificity — 83,3%, positive predictive value — 93,5%, negative predictive value — 44,1%. Correlations between other components of the disease and high levels of the antibodies were not found.
Conclusions. We found a positive correlation between antibodies against NALP5 and hypoparathyroidism in APS type 1 patients. We did not find correlations between antibodies against NALP5 and other components of APS type 1.
About the Authors
Leila S. Sozaeva
Endocrinology Research Centre
Russian Federation
MD
Competing Interests: нет конфликта интересов
Russian Federation
MD
Competing Interests: нет конфликта интересов
Elizaveta M. Orlova
Endocrinology Research Centre;
I.M. Sechenov First Moscow State Medical University
Russian Federation
MD, PhD, Leading researcher
Competing Interests: нет конфликта интересов
Russian Federation
MD, PhD, Leading researcher
Competing Interests: нет конфликта интересов
Bergithe Oftedal
University of Bergen
Norway
PhD, post doctoral fellow (University of Bergen, N-5020 Bergen, Norway).
Norway
PhD, post doctoral fellow (University of Bergen, N-5020 Bergen, Norway).
Maria A. Kareva
Endocrinology Research Centre
Russian Federation
Competing Interests: нет конфликта интересов
Russian Federation
Competing Interests: нет конфликта интересов
Valentina A. Peterkova
Endocrinology Research Centre;
I.M. Sechenov First Moscow State Medical University
Russian Federation
MD, PhD, Professor, Head of the Pediaric endocrinology department
Russian Federation
MD, PhD, Professor, Head of the Pediaric endocrinology department
Ivan I. Dedov
Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Academician of Russian academy of sciences, director of Endocrinology Research Centre
Russian Federation
MD, PhD, Professor, Academician of Russian academy of sciences, director of Endocrinology Research Centre
Eystein Sverre Husbye
University of Bergen
Norway
MD, PhD, Professor, head of the Endocrinology group, University of Bergen, N-5020 Bergen, Norway
Norway
MD, PhD, Professor, head of the Endocrinology group, University of Bergen, N-5020 Bergen, Norway
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Review
For citations:
Sozaeva L.S., Orlova E.M., Oftedal B., Kareva M.A., Peterkova V.A., Dedov I.I., Husbye E.S. Antibodies against NALP5 and it’s role in hypoparathyroidism in autoimmune polyglandular syndrome type 1. Problems of Endocrinology. 2016;62(2):25-30. https://doi.org/10.14341/probl201662225-30
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