HCG-secreting hepatoblastoma
https://doi.org/10.14341/probl2017632127-129
Abstract
We describe a case of precocious sexual development in a 4-year-old boy, which was caused by HCG-secreting hepatoblastoma. The precocious sexual development manifested two months after starting polychemotherapy for hepatoblastoma, which presented as the emergence and rapid progression of pubic hair, low voice, and acceleration of the growth rate and bone age. The size of the testicles remained at the prepubertal level. We, together with oncologists, developed a therapeutic tactics: surgical removal of the tumor after the fourth course of polychemotherapy. Antiandrogenic drugs were not used because of their hepatotoxicity and inefficacy in this clinical situation.
About the Authors
Darya N. KorolevaRepublican children’s clinical hospital
Russian Federation
MD
Tatiana S. Olina
Republican children’s clinical hospital
Russian Federation
MD
Tatiana V. Kovalenko
Izhevsk State Medical Academy
Russian Federation
DMD, PhD, Professor
References
1. Дедов И. И., Петеркова В. А. Руководство по детской эндокринологии. — М.: Универсум Паблишинг; 2006. [Dedov II, Peterkova VA. Rukovodstvo po detskoy endokrinologii. Moscow, Universum Publishing; 2006 (in Russ).]
2. Федеральные клинические рекомендации (протоколы) по ведению детей с эндокринными заболеваниями / под ред. И.И. Дедова, В.А. Петерковой — М.: Практика; 2014. [Dedov II, Peterkova VA, editors. Russian clinical healthcare guidelines (protocols) for children with endocrine diseases. Moscow: Praktika; 2014. (In Russ).]
3. Клинические рекомендации по лечению злокачественных опухолей печени у детей / под ред. академика РАН, главного детского онколога МЗ РФ В.Г. Полякова — М.: НИИ детской онкологии и гематологии; 2014. [Polyakov VG, editor.Clinical guidelines for children hepatic cancer treatment. Moscow: NII detskoy onkologii i gematologii; 2014. (In Russ).]
4. Алиев М.Д., Поляков В.Г. Детская онкология. Национальное руководство — М.: Издательская группа РОНЦ, Практическая медицина; 2012. [Aliev MD, Polyakov VG. Pediatric oncology. National guidelines. Moscow: RONC, Prakticheskaya medicina; 2012 (In Russ).]
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For citations:
Koroleva D.N., Olina T.S., Kovalenko T.V. HCG-secreting hepatoblastoma. Problems of Endocrinology. 2017;63(2):127-129. https://doi.org/10.14341/probl2017632127-129
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