Preview

User

Not a user? Register with this site Forgot your password?

Problems of Endocrinology

Advanced search

Correlation between type 2 diabetes mellitus and air pollution with suspended particles

https://doi.org/10.14341/probl9626

Abstract

The review presents the modern concept of the relationship between air pollution with fine particulate matter (PM) and the prevalence of diabetes mellitus (DM). The role of PM in the pathogenesis of DM, in particular, DM2, depending on their size, origin, chemical composition, and concentration in the air is discussed. For this purpose, we used materials from the articles indexed in the PubMed and RSCI databases. Road transport-related PM, containing intermediate valence metals are believed to be the most dangerous ones. Long-term exposure to high concentrations of fine and ultrafine PM is associated with the risk of type 2 diabetes and mortality. Short-term exposure to PM causes vascular insulin resistance and inflammation triggered by oxidative stress in the lungs. Oxidative stress caused by exposure to PM is the central stage of inflammatory reactions, leading to release of pro-inflammatory cytokines from cells and systemic inflammation. Exposure to PM sized 2.5 microns or less results in significant increase in expression of proinflammatory genes and activation of corresponding signaling pathways. Involvement of PM into impairment of glucose homeostasis and increase in inflammation in adipose tissue, liver, and central nervous system has been confirmed in models and experimental studies. The role of air pollution with PM in the pathogenesis of type 2 diabetes is still not fully understood, especially at the molecular and cellular level. The development of formalized descriptions of the processes mediating the effect of PM on the human body will provide better understanding of the role of air pollution with suspended particles in the pathogenesis of various diseases and, in particular, DM2, which can contribute to improvement of treatments and preventive measures.

About the Authors

Alla F. Kolpakova

Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences


Russian Federation

MD, PhD, professor


Ruslan N. Sharipov

BIOSOFT.RU LLC; Novosibirsk State University


Russian Federation

project manager; senior teacher


Oxana A. Volkova

Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences


Russian Federation

PhD


References

1. Дедов И.И., Омельяновский В.В., Шестакова М.В. и др. Сахарный диабет как экономическая проблема в Российской Федерации. // Cахарный диабет. — 2016. — Т. 19. — №1. – С. 30—43. [Dedov II, Omelyanovskiy VV, Shestakova MV, et al. Diabetes mellitus as an economic problem in Russian Federation. Diabetes Mellitus. 2016;19(1):30-43. (In Russ.)]. doi:https://doi.org/10.14341/dm77842

2. International Diabetes Federation. IDF Atlas. 7th Ed. Brussels: Idf; 2015.

3. Дедов И.И., Шестакова М.В., Галстян Г.Р. Распространен ность сахарного диабета 2-го типа у взрослого населения России (исследование Nation). // Сахарный диабет. — 2016. — Т. 19. — №2. — С. 104—112. [Dedov II, Shestakova MV, Galstyan GR. The Prevalence of type 2 diabetes mellitus in the adult population of Russia (Nation Study). Diabetes Mellitus. 2016;19(2):104-112. (In Russ.)]. doi: https://doi.org/10.14341/dm2004116-17

4. Шестакова М.В., Дедов И.И. Сахарный диабет в Российской Федерации: аргументы и факты. // Терапевтический архив. — 2016. — Т. 88. — №10. — С. 4—8. [Shestakova MV, Dedov II. Diabetes mellitus in Russian Federation: arguments and Facts. Ter Arkh. 2016;88(10):4-8. (In Russ.)]. doi: https://doi.org/10.17116/terarkh201688104-8

5. Apte JS, Marshall JD, Cohen AJ, Brauer M. Addressing global mortality from ambient Pm2.5. Environ Sci Technol. 2015;49(13): 8057-8066. doi: https://doi.org/10.1021/acs.est.5b01236

6. World Health Organization. Global Status Report On Noncommunicable Diseases. WHO (Geneva). 2014.

7. Héroux ME, Braubach M, Korol N, и др. Основные выводы о медицинских аспектах загрязнения воздуха: Проекты Revihaap и Hrapie ВОЗ/ЕК // Гигиена и санитария. — 2013. — Т. 92. — №6. — С. 9—14. [Héroux Me, Braubach M, Korol N, et al. The Main conclusions about the medical aspects of air pollution: the projects revihaap and hrapie WHO/EC. Gig Sanit. 2013;92(6):9-14. (In Russ.)].

8. WHO.Int [Internet]. Ambient (Outdoor) Air Quality And Health [Cited 2018 Sep 16]. Available From: doi://http://www.who.int/mediacentre/factsheets/fs313/en/

9. О cостоянии и об охране окружающей среды Российской Федерации в 2015 г. Государственный доклад. / Под ред. Рыбальского Н.Г. М.: НИА-Природа; 2016. [Rybalskiy NG, Editor. O sostoyanii i ob okhrane okruzhayushchey sredy Rossiyskoy Federatsii v 2015. State Report. Moscow: NIA-Priroda; 2016. (In Russ.)].

10. Balti EV, Echouffo-Tcheugui JB, Yako YY, Kengne AP. Air pollution and risk of type 2 diabetes mellitus: a systematic review and metaanalysis. Diabetes Res Clin Pract. 2014;106(2):161-172. doi: https://doi.org/10.1016/j.diabres.2014.08.010

11. Wang B, Xu D, Jing Z, et al. Effect of long-term exposure to air pollution on type 2 diabetes mellitus risk: a systemic review and metaanalysis of cohort studies. Eur J Endocrinol. 2014; 171(5):R173-R182. doi: https://doi.org/10.1530/eje-14-0365

12. Eze IC, Hemkens LG, Bucher HC, et al. Association between ambient air pollution and diabetes mellitus in Europe and North America: systematic review and metaanalysis. Environ Health Perspect. 2015;123(5):381-389. doi: https://doi.org/10.1289/ehp.1307823

13. Thiering E, Heinrich J. Epidemiology of air pollution and diabetes. Trends Endocrinol Metab. 2015;26(7):384-394. doi: https://doi.org/10.1016/j.tem.2015.05.002

14. Meo SA, Memon AN, Sheikh SA, et al. Effect of environmental air pollution on type 2 diabetes mellitus. Eur Rev Med Pharm Sci. 2015;19:123-128.

15. Esposito K, Petrizzo M, Maiorino MI, et al. Particulate matter pollutants and risk of type 2 diabetes: a time for concern? Endocrine. 2016;51(1):32-37. doi: https://doi.org/10.1007/s12020-015-0638-2

16. He D, Wu S, Zhao H, et al. Association between particulate matter 2.5 and diabetes mellitus: a metaanalysis of cohort studies. J Diabetes Investig. 2017;8(5):687-696. doi: https://doi.org/10.1111/jdi.12631

17. Park SK, Adar SD, O’neill MS, et al. Long-term exposure to air pollution and type 2 diabetes mellitus in a multiethnic cohort. Am J Epidemiol. 2015;181(5):327-336. doi: https://doi.org/10.1093/aje/kwu280

18. Weinmayr G, Hennig F, Fuks K, et al. Long-term exposure to fine particulate matter and incidence of type 2 diabetes mellitus in a cohort study: effects of total and traffic-specific air pollution. Environ Health. 2015;14:53. doi: https://doi.org/10.1186/s12940-015-0031-x

19. Hansen Ab, Ravnskjaer L, Loft S, et al. Long-term exposure to fine particulate matter and incidence of diabetes in the Danish nurse cohort. Environ Int. 2016;91:243-250. doi: https://doi.org/10.1016/j.envint.2016.02.036

20. Franck U, Odeh S, Wiedensohler A, et al. The effect of particle size on cardiovascular disorders — the smaller the worse. Sci Total Environ. 2011;409(20):4217-4221. doi: https://doi.org/10.1016/j.scitotenv.2011.05.049

21. Kim Kh, Kabir E, Kabir S. A review on the human health impact of airborne particulate matter. Environ Int. 2015;74:136-143. doi: https://doi.org/10.1016/j.envint.2014.10.005

22. Chen H, Burnett RT, Kwong JC, et al. Risk of incident diabetes in relation to long-term exposure to fine particulate matter in Ontario, Canada. Environ Health Perspect. 2013;121(7):804-810. doi: https://doi.org/10.1289/ehp.1205958

23. Park SK, Wang W. Ambient air pollution and type 2 diabetes: a systematic review of epidemiologic research. Curr Environ Health Rep. 2014;1(3):275-286. doi: https://doi.org/10.1007/s40572-014-0017-9

24. Qiu H, Schooling CM, Sun S, et al. Long-term exposure to fine particulate matter air pollution and type 2 diabetes mellitus in elderly: a cohort study in Hong Kong. Environ Int. 2018;113:350-356. doi: https://doi.org/10.1016/j.envint.2018.01.008

25. Ward-Caviness CK, Kraus WE, Blach C, et al. Association of roadway proximity with fasting plasma glucose and metabolic risk factors for cardiovascular disease in a cross-sectional study of cardiac catheterization patients. Environ Health Perspect. 2015; 123(10):1007-1014. doi: https://doi.org/10.1289/ehp.1306980

26. Samoli E, Stafoggia M, Rodopoulou S, et al. Which specific causes of death are associated with short term exposure to fine and coarse particles in Southern Europe? Results from the med-particles project. Environ Int. 2014;67:54-61. doi: https://doi.org/10.1016/j.envint.2014.02.013

27. Li C, Fang D, Xu D, et al. Main air pollutants and diabetes-associated mortality: a systematic review and metaanalysis. Eur J Endocrinol. 2014;171(5):R183-190. doi: https://doi.org/10.1530/eje-14-0287

28. Brook RD, Cakmak S, Turner MC, et al. Long-term fine particulate matter exposure and mortality from diabetes in Canada. Diabetes Care. 2013;36(10):3313-3320. doi: https://doi.org/10.2337/dc12-2189

29. Solimini AG, D’addario M, Villari P. Ecological correlation between diabetes hospitalizations and fine particulate matter in Italian provinces. BMC Public Health. 2015;15:708. doi: https://doi.org/10.1186/s12889-015-2018-5

30. De Berardis G, D’ettorre A, Graziano G, et al. The burden of hospitalization related to diabetes mellitus: a population-based study. Nutr Metab Cardiovasc Dis. 2012;22(7):605-612. doi: https://doi.org/10.1016/j.numecd.2010.10.016

31. Дедов И.И., Шестакова М.В., Викулова О.К. Государственный регистр сахарного диабета в Российской Федерации: статус 2014 г. и перспективы зазвития // Сахарный диабет. — 2015. — Т. 18. — №3. — С. 5—22. [Dedov II, Shestakova MV, Vikulova OK. The state register of diabetes mellitus in Russian Federation: status in 2014 and the prospect for development. Diabetes Mellitus. 2015;18(3):5-22. (In Russ.)]. doi: https://doi.org/10.14341/dm201535-22

32. Ткачук В.А., Воротников А.В. Молекулярные механизмы развития резистентности к инсулину. // Сахарный диабет. — 2014. — Т. 17. — №2. — С. 29—40. [Tkachuk VA, Vorotnikov AV. Molecular mechanisms of insulin resistance development. Diabetes Mellitus. 2014;17(2):29-40. (In Russ.)]. doi: https://doi.org/10.14341/dm2014229-40

33. Rao X, Patel P, Puett R, Rajagopalan S. Air pollution as a risk factor for type 2 diabetes. Toxicol Sci. 2015;143(2):231-241. doi: https://doi.org/10.1093/toxsci/kfu250

34. Brook RD, Xu X, Bard RL, et al. Reduced metabolic insulin sensitivity following sub-acute exposures to low levels of ambient fine particulate matter air pollution. Sci Total Environ. 2013;448:66-71. doi: https://doi.org/10.1016/J.Scitotenv.2012.07.034

35. Chen Z, Salam MT, Toledo-Corral C, et al. Ambient air pollutants have adverse effects on insulin and glucose homeostasis in Mexican Americans. Diabetes Care. 2016;39(4):547-554. doi: https://doi.org/10.2337/dc15-1795

36. Yitshak Sade M, Kloog I, Liberty IF, et al. The association between air pollution exposure and glucose and lipids levels. J Clin Endocrinol Metab. 2016;101(6):2460-2467. doi: https://doi.org/10.1210/jc.2016-1378

37. Liu C, Xu X, Bai Y, et al. Air pollution-mediated susceptibility to inflammation and insulin resistance: influence of CCR2 pathways in mice. Environ Health Perspect. 2014;122(1):17-26. doi: https://doi.org/10.1289/ehp.1306841

38. Potera C. Toxicity beyond the lung: connecting Pm2.5, inflammation, and diabetes. Environ Health Perspect. 2014;122(1):A29. doi: https://doi.org/10.1289/ehp.122-a29

39. Hampel R, Peters A, Beelen R, et al. Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts. Environ Int. 2015;82:76-84. doi: https://doi.org/10.1016/j.envint.2015.05.008

40. Haberzettl P, O’toole TE, Bhatnagar A, Conklin DJ. Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress. Environ Health Perspect. 2016;124(12):1830-1839. doi: https://doi.org/10.1289/ehp212

41. Liu C, Bai Y, Xu X, et al. Exaggerated effects of particulate matter air pollution in genetic type II diabetes mellitus. Part Fibre Toxicol. 2014;11:27. doi: https://doi.org/10.1186/1743-8977-11-27

42. Peng C, Bind MC, Colicino E, et al. Particulate air pollution and fasting blood glucose in nondiabetic individuals: associations and epigenetic mediation in the normative aging study, 2000—2011. Environ Health Perspect. 2016;124(11):1715-1721. doi: https://doi.org/10.1289/ehp183

43. Dai L, Mehta A, Mordukhovich I, et al. Differential DNA methylation and PM2.5 species in a 450K epigenome-wide association study. Epigenetics. 2017;12(2):139-148. doi: https://doi.org/10.1080/15592294.2016.12718533

44. Bekki K, Ito T, Yoshida Y, et al. PM2.5 collected in China causes inflammatory and oxidative stress responses in macrophages through the multiple pathways. Environ Toxicol Pharmacol. 2016; 45:362-369. doi: https://doi.org/10.1016/j.etap.2016.06.022

45. Ding R, Jin Y, Liu X, et al. Characteristics of DNA methylation changes induced by traffic-related air pollution. Mutat Res Genet Toxicol Environ Mutagen. 2016;796:46-53. doi: https://doi.org/10.1016/j.mrgentox.2015.12.002

46. Nilsson E, Jansson PA, Perfilyev A, et al. Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes. 2014;63(9):2962-2976. doi: https://doi.org/10.2337/db13-1459


Supplementary files

1. A formalized description of the effect of PM2.5 on the development of insulin resistance and systemic inflammation (the processes underlying the pathogenesis of diabetes).
Subject
Type Исследовательские инструменты
View (864KB)    
Indexing metadata ▾

Review

For citations:

Kolpakova A.F., Sharipov R.N., Volkova O.A. Correlation between type 2 diabetes mellitus and air pollution with suspended particles. Problems of Endocrinology. 2018;64(5):329-335. https://doi.org/10.14341/probl9626

Views: 1170


ISSN 0375-9660 (Print)
ISSN 2308-1430 (Online)

11, Dm. Ul’yanova str., Moscow, Russian Federation, 117292

Processing of personal data
supported by NEICON (Elpub lab)