Cellular immunity of patients with newly detected insulin-dependent diabetes
https://doi.org/10.14341/probl199440117-20
Abstract
Twenty-five diabetics with insulin-dependent condition were examined at the debut of the disease before insulin therapy, as were 10 healthy donors. Under study were relative and absolute counts of T lymphocytes, NK cells, В lymphocytes, DR-T lymphocytes, Th, Ts, and Th/Ts index. Patients’ and donors’ sera were tested for autoantibodies to P64 —69kD antigenic complex. Characteristic features of cellular immunity of patients with newly-detected diabetes were disclosed. Counts of В lymphocytes and Dr-T lymphocytes were increased in all patients. A relationship was revealed between immunoregulatory Th/Ts index and clinical features of insulin-dependent diabetes. Autoantibodies to p64—68 kD andigenic complex were detected in 63-88 % of patients with newly detected insulin-dependent diabetes.
About the Authors
I I DedovEndocrinology Research Centre
Russian Federation
L A Chugunova
Endocrinology Research Centre
Russian Federation
O M Smirnova
Endocrinology Research Centre
Russian Federation
S V Brykova
Endocrinology Research Centre
Russian Federation
T S Schegolkova
Endocrinology Research Centre
Russian Federation
References
1. Балаболкин М. И. // Пробл. эндокринол,— 1984.— № 3,— С. 37—38.
2. Ефимов А. С., Полторак В. В. // Там же.— 1987.— № 6,— С. 80—88.
3. Al-Kassab A. S., Razuiddin S. // Clin. exp. Immunol.— 1990,—Vol. 81,— P. 267—271.
4. Al-Sakkaf L., Pozzilli P., Farn A. S. et al. // Diabetolo¬gia.— 1989,— Vol. 32,— P. 322—325.
5. Baekkeskov S., Christie M., Rajotte R. V. et al // Ibid.— 1987,— Vol. 30.— P. 495A-496A.
6. Bottazzo G. F., Pujol-Borrell R., Hanafusa T. et al. 11 Lancet.- 1983,-Vol. 2,-P. 1115-1119.
7. Bottazzo G. F., Dean В. M., McNally J. M. et al. // New Engl. J. Med.— 1985,—Vol. 313, N 6.—P. 353—360.
8. Christie M., Landin-Olsson M., Sundkvist G. et al. // Diabetologia.— 1988,—Vol. 31, N 8,—P. 597—602.
9. Drell D. №.. Notkins A. L. 11 Ibid.— 1987.— Vol. 30.— P. 132—143.
10. Eisenbarth G. S. // New Engl. J. Med.— 1986.— Vol. 314.— P. 1360—1368.
11. Jackson R. A. et al. // Ibid.— 1982.— Vol. 306.— P. 785— 788.
12. Koewary S., Rossini A., Stoller №. et al. // Science.— 1983,— Vol. 220,— P. 727—728.
13. Kolb H. 11 IDF Bull.— 1990,-Vol. 35, N 2,— P. 37—39.
14. Mascart-Lemone F. et al. // Clin. exp. Immunol.— 1982 — Vol. 47,— P. 296—300.
15. Moffitt J. E„ Guill M. F„ Leffell M. S. et al. // J. Allergy.— 1989,—Vol. 84, N 2,—P. 191 — 196.
16. Nerup I., Lernmark A. // Amer. J. Med.— 1981.— Vol. 70, N 1,— P. 135—141.
17. Riley №. // Clin. Immunol. Immunopath.— 1989.— Vol. 53, N 2,— Pt 2,— P. 92—98.
Review
For citations:
Dedov I.I., Chugunova L.A., Smirnova O.M., Brykova S.V., Schegolkova T.S. Cellular immunity of patients with newly detected insulin-dependent diabetes. Problems of Endocrinology. 1994;40(1):17-20. (In Russ.) https://doi.org/10.14341/probl199440117-20
Views:
1794
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
