Complications of type I diabetes mellitus and HLA antigens
https://doi.org/10.14341/probl19954154-7
Abstract
HLA antigens were studied by 67 markers in 95 children and adolescents with diabetes mellitus of at least 5 years standing. Screening of late complications of diabetes was carried out in this group. Analysis of correlations revealed HLA markers of discrete predisposition to various complications of the disease. Relationship between diabetes duration and the development of retinopathy, nephropathy, and development of more than one complication was revealed. At the same time, limited mobility of the joints (diabetic cheiropathy) was found to be unrelated to HLA antigens or diabetes duration.
About the Authors
N B LebedevEndocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
V V Yazdovskiy
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
L N Shcherbacheva
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
T L Kuraeva
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
V P Maksimova
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
A P Sergienko
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
N V Gubanov
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
E A Andriyanova
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
V N Ilyukhin
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
I V Osokina
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
I I Dedov
Endocrinology research center of RAMS; Institute of immunology of the Ministry of health and industry
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Review
For citations:
Lebedev N.B., Yazdovskiy V.V., Shcherbacheva L.N., Kuraeva T.L., Maksimova V.P., Sergienko A.P., Gubanov N.V., Andriyanova E.A., Ilyukhin V.N., Osokina I.V., Dedov I.I. Complications of type I diabetes mellitus and HLA antigens. Problems of Endocrinology. 1995;41(5):4-7. (In Russ.) https://doi.org/10.14341/probl19954154-7
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