Features of the immune status in patients with coronary heart disease with obesity and atherogenic dyslipidemia

Immunity parameters (Т lymphocytes with CD4\ CDS*, CD95⁺ markers and circulating immune complexes (CIC) with IgM) and the eyeball conjunctival vessels were studied in patients with angiographically documented coronary atherosclerosis with and without metabolic syndrome (MS) with the aim of detecting a relationship between immunological and metabolic parameters. T lymphocyte subpopulations were evaluated by indirect immunoperoxidase test with monoclonal antibodies. High levels of cytotoxic lymphocytes (CDS*) and T cells with Fas molecule were detected in coronary patients with MS, but not in coronary patients without MS. The concentration of CIC with IgM was the highest in patients with MS, which may be conducive to capillary damage. Biomicroscopy of conjunctival vessels detected more pronounced disorders in microcirculation in coronary patients with MS, presenting as a significant increase in the conjunctival indexes in this group in comparison with coronary patients without MS. Statistically significant correlations were detected between CD95* marker and body weight index, atherogenic lipid metabolism parameters, and creatine phosphokinase levels. Abnormal activation of Fas system may be involved in the pathogenesis of ischemic injuries to various organs or in autoimmune processes mediated by cytotoxic lymphocytes.

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