Diagnostic value of high performance liquid chromatography of corticosteroids in diseases of the pituitary system
https://doi.org/10.14341/probl20055169-11
Abstract
A hundred and ninety-one patients with different adrenal cortical tumors were studied to assess the diagnostic value of HPLC of corticosteroids in the biological fluids. HPLC of corticosteroids in the biological fluids revealed the signs of the hormonal activity of incidentalomas, organic endogenous hypercorticism, and mass malignancy. Some patients with adrenal cortical incidentalomas (15.5%) were found to have impaired steroid formation that is typical of 11β-OH- or 17-OH-hydroxylase deficiencies. The findings allow one to diagnose adrenal disorders at the early stages of disease and to define indications for surgical treatment.
About the Authors
L. I. VelikanovaSaint-Petersburg medical academy for postgraduate education
Russian Federation
Z. R. Shafigullina
Saint-Petersburg medical academy for postgraduate education
Russian Federation
N. V. Vorokhobina
Saint-Petersburg medical academy for postgraduate education
Russian Federation
P. A. Silnitsky
Saint-Petersburg medical academy for postgraduate education
Russian Federation
Ye. A. Bessonova
Saint-Petersburg medical academy for postgraduate education
Russian Federation
References
1. Великанова Л.И., Карцева Л.А., Бессонова Е.А. // Между-народная конф. по теоретическим вопросам адсорбции и адсорбционной хроматографии: Сборник тезисов докла-дов, 2001. - С. 55.
2. Гончаров Н.П., Кация Г.В., Колесникова Г.В. и др. // Пробл. эндокринол. - 2000. - Т. 46, № 5. - С. 21-25.
3. Синдром Иценко-Кушинга / Под ред. В. Г. Баранова. - М., 1988.
4. Angeli A., Osella G., Аli A., Terzolo М. // Horm. Res. - 1997. - Vol.47. - P. 279-283.
5. Chidiac R.M., Aron D.C. // Endocrinol. Metab. Clin. N. Am. - 1997. - Vol.26. - P. 233-253.
6. Mantero F., Terzolo M., Arnaldi G. et al. // J. Clin. Endocri-nol. Metab. - 1999. - Vol. 85. - P. 637-644.
7. Ozella G., Terzolo M., Boretta G. et al. // J. Clin. Endocrinol. Metab. - 1996. - Vol.79. - P. 1532-1539.
8. Reincke M., Peter M., Sippell W.G., Allolio B. // Eur. J. En-docrinol. - 1997. - Vol.136. - P. 196-200.
9. Rossi R., Tauchmanova L., Luciano A. et al. // J. Clin. Endo-crinol. Metab. - 1999. - Vol.85. - P. 1440-1448.
10. Schoneshofer M., Weber В., Oelkers W. et al. // Clin. Chem. - 1986. - Vol.32. - P. 93-96.
11. Suzuki Т., Sakuta H., Nakagawa K. et al. // Nippon Naibunpi Gakkai Zasshi. - 1993. - Vol.69. - P. 1139-1152.
12. Taylor R.L., Machacek D., Singh R.J. // Clin. Chem. - 2002. - Vol.48. - P. 1511-1519.
13. Turpeinen U., Stenman U.H. // Scand. J. Clin. Lab. Invest. - 2003. - Vol.63. - P. 143.
14. Ueshiba H., Segawa M., Hayashi T. et al. // Clin. Chem. - 1991. - Vol.37. - P. 1329-1333.
Review
For citations:
Velikanova L.I., Shafigullina Z.R., Vorokhobina N.V., Silnitsky P.A., Bessonova Ye.A. Diagnostic value of high performance liquid chromatography of corticosteroids in diseases of the pituitary system. Problems of Endocrinology. 2005;51(6):9-11. (In Russ.) https://doi.org/10.14341/probl20055169-11
Views:
1237
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
