Biochemical markers of congenital adrenal hyperplasia and impaired steroidogenesis
https://doi.org/10.14341/probl200753130-33
Abstract
The paper deals with the problems In the biochemical diagnosis of congenital adrenal hyperplasia caused mainly by adrenal 21-hydroxylase deficiency. It presents data on the adrenal cortical synthesis of corticosteroids and discusses whether different biochemical markers, including the levels of blood deoxycortisol and those of urinary pregnantriol and pregnantriolone, may be used in neonatal screening and later diagnosis of congenital adrenal hyperplasia.
About the Authors
N. P. GoncharovEndocrinology Research Centre
Russian Federation
G. S. Kolesnikova
Endocrinology Research Centre
Russian Federation
References
1. Гончаров Н. П., Колесникова Г. С. // Кортикостероиды: метаболизм, механизм действия и клиническое применение. - М., 2002.
2. Bachega Т. А, Billerbeck A. Е., Marcondes J. A et al // Clin. Endocrinol. (Oxford).'- 2000. - Vol. 52, N 5. - P. 601- 607.
3. Bristow J., Gitelman S. E., Tee M. K. et al. // J. Biol. Chem. - 1993. - Vol. 268. - P. 12919-12923.
4. Brotherton J., Rothbart В // J. Steroid Biochem. - 1990 - Vol. 28, N 6. - P. 641-649.
5. Charmandari E., Pincus S. M., Matthews D. R. et al. // J. Clin. Endocrinol. Metab. - 2002. - Vol. 87, N 5. - P. 2238- 2244.
6. Сharmandari E, Merke D. P., Negro P. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 5. - P. 2228-2236.
7. Franks R. S. // J. Clin. Endocrinol. Metab. - 1974. - Vol. 39, N 6. - P. 1099-1103.
8. Geley S., Peter A/., Johrer K. et al. // Exp. Clin. Endocrinol. - 1993. - Vol. 101. - Suppl. 1. - P. 15-31.
9. Gueux В., Fiet J., Pham-Huu-Tsung M. T. et al. // Acta Endocrinol. (Copenh.). - 1985. - Vol. 108, N 4. - P. 537-544.
10. Homma // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 12. - P. 6087-6091.
11. Kao P. C, Machacek D. A, Magera M. J. et al. // Ann. Clin. Lab. Sci. - 2001. - Vol. 31, N 2. - P. 199-204.
12. VAllemand D., Tardy V., Gruters A. et al. // J. Clin. Endocrinol. Metab. - 2000. - Vol. 85, N 12. - P. 4562-4567.
13. Maitra A., Shirwalkar H. // Indian J. Exp. Biol. - 2003. - Vol. 41, N 7. - P. 701-709.
14. Mellon S. H., Miller W. L. // J. Clin. Invest. - 1989. -Vol. 84. - P. 1497-1501.
15. Merke D. P. et al. // Fertil. and Stenl. - 2000. - Vol. 74, N 2. - P. 329-334.
16. Minutti С Z., Lacey J. M., Magera M. J. et al. // J. Clin. Endocrinol. Metab. - 2004. - Vol. 89, N 8. - P. 3687-3693.
17. Morel Y., Miller W. L. // Adv. Hum. Genet. - 1991. -Vol. 20. - P. 1-4.
18. Nahoul K, Adeline J., Bercovici J. P. et al. // J. Steroid Biochem. - 1989. - Vol. 33, N 6. - P. 1167-1172.
19. New M. I. И Ann. N. Y. Acad. Sci. - 2004. - Vol. 1038. -P. 14-43.
20. Saisho S., Shimozawa K, lata J. et al. // Horm. Res. - 1990. - Vol. 33, N 1. - P. 27-34.
21. White P. C, New M. J., Dupont B. // Proc. Natl. Acad. Sci. USA. - 1986. - Vol. 83. - P. 5-10.
Review
For citations:
Goncharov N.P., Kolesnikova G.S. Biochemical markers of congenital adrenal hyperplasia and impaired steroidogenesis. Problems of Endocrinology. 2007;53(1):30-33. (In Russ.) https://doi.org/10.14341/probl200753130-33
Views:
3646
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
