The efficacy and safety of the insulin analogue de-temir (levemir): Clinical observation

Abstract

Type 1 diabetes mellitus in children and adolescents is characterized by marked lability of the course, as well as the difficulty in achieving compensation for carbohydrate metabolism. Sudden changes in glycemia during the day lead to the development of vascular complications. Features of adolescence (unwillingness to diet and regularly administer insulin “so as not to stand out among peers”) and the presence of the “morning dawn” phenomenon in adolescents lead to decompensation of diabetes mellitus and an increased need for insulin. An increase in the dose of insulin is one of the reasons for the development of hypoglycemic conditions. Rational insulin therapy allows not only to achieve normoglycemia, but also to avoid explicit and latent hypoglycemia and thereby prevent or slow the development of micro- and macrovascular complications.