The cardiovascular system in patients with symptomatic and mild primary hyperparathyroidism
https://doi.org/10.14341/probl200955325-29
Abstract
The cardiovascular system was analyzed in patients with symptomatic (n = 31) and mild primary hyperparathyroidism (n = 34) whose mean age was 54.6 years; 95% females). In the patients with symptomatic primary hyperparathyroidism, the PQ interval was longer and the QT interval was significantly shorter than those in patients with mild hyperparathyroidism. Left ventricular hypertrophy was noted in 45.2% of patients with symptomatic and in 15.2% of those with mild hyperparathyroidism (p = 0.013). Left ventricular diastolic dysfunction was also more common in the group of symptomatic hyperparathyroidism. There was a statistically significant correlation between the levels of parathyroid hormone, total and ionized calcium and the duration of QT interval and the determinants of diastolic function and left ventricular hypertrophy. The revealed cardiovascular disorders in patients with primary hyperparathyroidism are presumed to depend on the increase rate of parathyroid hormone and total and ionized calcium.
About the Authors
I V VoronenkoI.M.Sechenov Moscow state medical academy
Russian Federation
N G Mokrysheva
Endocrinology Research Centre
Russian Federation
L Ya Rozhinskaya
Endocrinology Research Centre
Russian Federation
A L Syrkin
I.M.Sechenov Moscow state medical academy
Russian Federation
References
1. Abergel E., Tase M., Bohlader J. // Am. J. Cardiol. - 1995. - Vol. 75. - P. 486-503.
2. Almqvuist E. G., Bondeson A. G., Bondeson L. et al. // Surgery. - 2002. - Vol. 132. - P. 1126-1132.
3. Anderson P., Rydberg E., Willenheimer R. // Eur. Heart J. - 2004. - Vol. 25, N 20. - P. 1776-1787.
4. Bilezikian J. P., Silverberg S. J. // N. Engl. J. Med. - 2004. - Vol. 350. - P. 1746-1751.
5. Bilezikian J. P. et al. // J. Clin. Endocrinol. - 2007. - Vol. 87, N 12. - P. 5353-5361.
6. Chang C. J., Chen S. A., Tai C. T. et al. // Pacing Clin. Electrophysiol. - 2000. - Vol. 23. - P. 534-537.
7. Curione M., Letizia C., Amato S. et al. // Int. J. Cardiol. - 2007. - Vol. 121, N 2. - P. 200-202.
8. Dalberg K., Brodin L. A., Juhlin-Dannfelt A. et al. // Eur. J. Surg. - 1996. - Vol. 162. - P. 171-176.
9. De La Torre N. G. et al. // Endocrine-Relat. Cancer. - 2003. - Vol. 10. - P. 309-322.
10. Devereux R. B., Alonso D. R., Lutas E. M. et al. // Am. J. Cardiol. - 1986. - Vol. 15. - P. 450-458.
11. Dominiczak A. F., Lyall F., Morton J. J. et al. // Clin. Sci. - 1990. - Vol. 78. - P. 127-132.
12. Du Bois D., Du Bois E. F. // Arch. Intern. Med. - 1916. - Vol. 17. - P. 863-971.
13. Hedback G., Tisell L. E., Bengtsson B. A. et al. // Wld J. Surg. - 1990. - Vol. 14. - P. 829-835.
14. Hedback G., Oden A. // Eur. J. Clin. Invest. - 1998. - Vol. 28. - P. 271-276.
15. Kearney P., Reardon M., O'Hare J. // Br. Heart J. - 1993. - Vol. 70. - P. 473.
16. Kosch M., Hausberg M., Vormbrock K. et al. // Am. J. Hypertens. - 2000. - Vol. 13. - P. 759-764.
17. Lдngle F., Abela C., Koller-Strametz J. et al. // Wld J. Surg. - 1994. - Vol. 18. - P. 619-624.
18. Lumachi F., Ermani M., Luisetto G. // Eur. J. Endocrinol. - 2002. - Vol. 146. - P. 643-647.
19. Mihai R., Wasst J. A., nSadler G. F. // Clin. Endocrinol. (Oxf.). - 2008. - Vol. 68, N 2. - P. 155-164.
20. Namboodiri N., Bohora S., Dora S. K. et al. // Singapore Med. J. - 2008. - Vol. 49, N 2. - P. 160-163.
21. Nappi S., Saha H., Virtanen V. et al. // Cardiology. - 2000. - Vol. 93. - P. 229-233.
22. Nilsson I. L., Aberg J., Rastad J. et al. // Surgery. - 1999. - Vol. 129. - P. 1049-1055.
23. Ochetta E., Borthic M., Magnani A. et al. // Europace. - 2004. - Vol. 6, N 3. - P. 184-188.
24. Ohara N., Hiramatsu K., Shigematsu S. et al. // Mineral Electrolyte Metab. - 1995. - Vol. 21, N 3. - P. 63-66.
25. Piovesan A., Molineri N., Casasso F. et al. // Clin. Endocrinol. (Oxf.). - 1999. - Vol. 50. - P. 321-328.
26. Rubin M. R., Mauer M. S., McMahon D. J. et al. // J. Clin. Endocrinol. - 2005. - Vol. 90. - P. 3326.
27. Sahn D. J., DeMaria A., Kissio J., Weyman A. // Circulation. - 1978. - Vol. 58. - P. 1072-1083.
28. Stefenelli T., Abela C., Frank H. et al. // J. Clin. Endocrinol. - 1997. - Vol. 82. - P. 106-112.
29. Suliburg J. W. // Oncologist. - 2007. - Vol. 12. - P. 644-653.
30. Taylor R., Wagoneer A. D. // J. Am. Soc. Echocardiogr. - 1992. - Vol. 5. - P. 603-612.
31. Uden P., Chan A., Duh Q. Y. t al. // Wld J. Surg. - 1992. - Vol. 16, N 4. - P. 791-797.
32. Wermers R. A., Khosla S., Atkinson E. J. et al. // Am. J. Med. - 1998. - Vol. 104. - P. 115-122.
Review
For citations:
Voronenko I.V., Mokrysheva N.G., Rozhinskaya L.Ya., Syrkin A.L. The cardiovascular system in patients with symptomatic and mild primary hyperparathyroidism. Problems of Endocrinology. 2009;55(3):25-29. (In Russ.) https://doi.org/10.14341/probl200955325-29
Views:
2522
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
