Analysis of allele polymorphism of A and В - DQ-HLA chain in patients with insulin-dependent diabetes mellitus and in a control group of Russian population
https://doi.org/10.14341/probl199743211-12
Abstract
Certain alleles of genes HLA-DQA1 and DQB1 may be regarded as reliable genetic markers of risk of insulin-dependent diabetes mellitus (IDDM) in the Russian population and in Caucasian populations. The presence of predisposing alleles Arg 52+ for DQA1 and Asp 57“ for DQB1 predicts a high risk of IDDM. The carriers of DQAl*0301, DQBl*0302, and DQBl*0201 are at the highest risk of the disease.
About the Authors
T. L. KurayevaEndocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
D. K. Gavrilov
Endocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
V. V. Nosikov
Endocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
A. S. Sergeyev
Endocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
V. P. Maximova
Endocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
N. B. Lebedev
Endocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
I. I. Dedov
Endocrinological Scientific Center of RAMS; State Scientific Center "GNII Genetics"; Medical and Genetic Scientific Center of RAMS
Russian Federation
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Review
For citations:
Kurayeva T.L., Gavrilov D.K., Nosikov V.V., Sergeyev A.S., Maximova V.P., Lebedev N.B., Dedov I.I. Analysis of allele polymorphism of A and В - DQ-HLA chain in patients with insulin-dependent diabetes mellitus and in a control group of Russian population. Problems of Endocrinology. 1997;43(2):11-12. (In Russ.) https://doi.org/10.14341/probl199743211-12
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