The study of the biological properties of structural analogues of sex steroids in order to create drugs

Abstract

Biological properties of structural analogs of sex steroids are studied. Alteration of the chemical structure of sex steroids helped single out a number of potential drugs possessing anabolic, antitumor, and contraceptive effects. Some potent estrogens may be used for replacement therapy. The biological characteristics of nitroxy derivative of ethynylestradiol nistranol are described in detail. This agent is characterized by an extremely high contraception index (4.6 times higher than ethynylestradiol). A new Russian two-component oral contraceptive Nitrogest has been developed, with the gestagenic component acetomepregnol synthesized at the Research Chemical Pharmaceutical Institute and the estrogen nistranol replacing the traditional ethynylestradiol.