Relationship between intestinal dysbiosis and iodine insufficiency in children with endemic goiter
https://doi.org/10.14341/probl11308
Abstract
Seventy-eight children aged 5— 10 years with diffuse euthyroid goiter, living in a region with slight iodine deficiency, were examined. Microbiological analysis o f feces showed stubborn intestinal dysbiocenosis in all children. Group 1 (n = 48) was treated by traditional antistrumin therapy for endemic goiter supplemented by routine correction of intestinal microbiocenosis. Group 2 (n = 30) was treated by antistrumin alone. After 3-month therapy the thyroid decreased in size in 93.6 and 10% patients in groups 1 and 2, respectively. Dynamic changes in the median o f urinary iodine excretion were observed in patients on regular iodine therapy in parallel with correction of intestinal microbiocenosis. Before iodine therapy this value was 70 ug/liter, after 3—6 months o f antistrumin therapy without correction of intestinal microbiocenosis it was 68 ug/liter, while after 3 months o f therapy including restoration o f intestinal microbiocenosis it increased to 100 ug/liter. These results confirm the involvement of normal intestinal microflora in iodine absorption in the gastrointestinal tract.
About the Authors
O. P. GrebnevaKazan State Medical Academy
Russian Federation
L. I. Anchikova
Kazan State Medical Academy
Russian Federation
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Review
For citations:
Grebneva O.P., Anchikova L.I. Relationship between intestinal dysbiosis and iodine insufficiency in children with endemic goiter. Problems of Endocrinology. 2001;47(1):26-28. (In Russ.) https://doi.org/10.14341/probl11308
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