The role of hormonal-cytokine interactions in the formation of humoral immune response
https://doi.org/10.14341/probl11347
Abstract
The functional activity of splenocytes of CBA mice was investigated in a syngeneic transfer system by the level of formation of antibody-producing cells (APC). Splenocytes were preincubated for 1 h in vitro with chorionic gonadotropin and type I recombinant interferons, as well as in hormonal-cytokine combinations. Chorionic gonadotropin in doses 10 and 50 MU/ml depressed APC formation, whereas alpha-interferon (250 MU/ml) stimulated it, and beta-interferon in the same concentration did not influence the level of humoral immune response. Chorionic gonadotropin, if added to splenocyte culture in combination with alpha-interferon, completely lost its immunodepressive properties. However, if together with alpha-interferon in a dose of 10 MU/ml it had a costimulating effect, in contrast to that, in combination with beta-interferon in the tested concentrations it was conducive to only a statistically reliable increase in the number of APC.
About the Author
S. V. ShirshevInstitute of ecology and genetics of microorganisms Uro RAS
Russian Federation
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For citations:
Shirshev S.V. The role of hormonal-cytokine interactions in the formation of humoral immune response. Problems of Endocrinology. 1995;41(1):32-34. (In Russ.) https://doi.org/10.14341/probl11347
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