The content of 3-hydroxyaminobtilyric acid, free insulin, and glucagon in patients with pancreatic diabetes
https://doi.org/10.14341/probl11468
Abstract
It is known that patients with insulin-dependent diabetes mellitus (IDDM) have a violation of insulin secretion. When insulin is discontinued or when exposed to stress, they can quickly develop diabetic ketoacidosis. The reason for this is a decrease in the content of free insulin in the blood. Patients with pancreatic diabetes (PD) (according to the WHO classification: diabetes associated with pancreatic disease) also have an endogenous violation of insulin secretion. However, they have less frequent diabetic ketoacidosis. Of 92 patients with chronic pancreatitis and PD, 11 (12%) patients had a history of positive reaction to ketone bodies at least once, and only 3 patients had ketoacidosis. When studying the excretion of a C-peptide with urine, it turned out that its content was not determined or was very insignificant both in patients with PD and patients with IDDM. Consequently, the origin of ketoacidosis cannot be associated only with the ability of the pancreas to secrete insulin. This article examined the mechanisms of ketoacidosis in patients with PD and IDDM. The activity of 3-hydroxybutyric acid (3-HMC) in the blood was determined as an indicator. At the same time, the content of free insulin and glucagon was measured.
About the Authors
Nakamura TeruoFaculty of medicine of Hirosaki University
Japan
Kudou Kendzi
Faculty of medicine of Hirosaki University
Japan
Terada Akinori
Faculty of medicine of Hirosaki University
Japan
Ishii Masataka
Faculty of medicine of Hirosaki University
Japan
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Review
For citations:
Teruo N., Kendzi K., Akinori T., Masataka I. The content of 3-hydroxyaminobtilyric acid, free insulin, and glucagon in patients with pancreatic diabetes. Problems of Endocrinology. 1995;41(5):7-10. (In Russ.) https://doi.org/10.14341/probl11468
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