The lymphocytic activity of nonspecific esterase and a-glycerophospate dehydrogenase in patients with autoimmune thyroiditis
https://doi.org/10.14341/probl11585
Abstract
Thirty-seven female patients with first diagnosed autoimmune thyroiditis (AIT) in the eurothyrosis phase and 15 healthy women were examined to establish a relationship between the activities of lym phocytic nonspecific esterase (NE) and α-glycerophospate dehydro genase (α-GPDH) and blood concentrations of thyrotropic, thyroid hormones, and hydrocortisone. The activities of α-GPDH and NE were evaluated by computer morphodensitometry. The activity of α- GPDH was higher in the lymphocytes of AIT patients, as man ifested by an increase in the optical density of granules. But this was not parallel by a rise in the area of diformasane granules, and therefore it is concluded that the enzymatic activity was increased without a pronounced synthesis and an increase in mitochondrial functional activity. Moreover, a morphodensitometric analysis showed higher NE activity, reflecting enhanced destructive reactions in the immu nocompetent cells in AIT.
About the Authors
S. G. KadrichevaInstitute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1
Russian Federation
A. A. Savchenko
Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No.1
Russian Federation
S. A. Dogadin
Institute of Medical Problems of the North SB RAMS; Endocrinology Center at the Regional Clinical Hospital No. 1
Russian Federation
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Review
For citations:
Kadricheva S.G., Savchenko A.A., Dogadin S.A. The lymphocytic activity of nonspecific esterase and a-glycerophospate dehydrogenase in patients with autoimmune thyroiditis. Problems of Endocrinology. 2003;49(3):14-18. (In Russ.) https://doi.org/10.14341/probl11585
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