Antithyroid autoimmune reactions and hyperprolactinemia in children and adolescents with allergic diseases
https://doi.org/10.14341/probl11607
Abstract
Endocrine status of 33 children suffering from allergic diseases (AD) was studied in order to detect the relationship between AD and autoimmune endocrinopathies and the probable effects of antihistaminic drugs on thyroid function and prolactin secretion. The group included 5 children with asthma, 8 with allergic dermatitis, 2 with allergic rhinitis, and 1 with relapsing angioneurotic edema. Asthma was concomitant with other allergic diseases in 17 children. Endocrinological study included evaluation of the thyroid morphology and function and two measurements of basal prolactin levels. 73% children with AD had a family history of autoimmune endocrinopathies. Autoimmune thyroiditis (AIT) predominated (30.3%) among thyroid diseases in the examined group. Diffuse endemic goiter was detected in 9.1% patients with AD. A combination of two and more AD and long allergic history were the most unfavorable factors promoting the development of AIT. Therapy for AD virtually did not influence the course of autoimmune endocrinopathy. Long therapy with histamine receptor blockers led to a 4.8 times increase in the incidence of hyperprolactinemia (HPRL). HPRL was associated with subclinical hypothyrosis in all cases and did not require dopaminomimetic therapy.
About the Authors
D. Ye. ShilinCentral Hospital # 6 MPS; RMAPO Ministry of Health of the Russian Federation
Russian Federation
N. I. Tsvetkova
Central Hospital # 6 MPS; RMAPO Ministry of Health of the Russian Federation
Russian Federation
N. A. Gorokhova
Central Hospital # 6 MPS; RMAPO Ministry of Health of the Russian Federation
Russian Federation
N. I. Bebisheva
Central Hospital # 6 MPS; RMAPO Ministry of Health of the Russian Federation
Russian Federation
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Review
For citations:
Shilin D.Ye., Tsvetkova N.I., Gorokhova N.A., Bebisheva N.I. Antithyroid autoimmune reactions and hyperprolactinemia in children and adolescents with allergic diseases. Problems of Endocrinology. 2002;48(3):13-18. (In Russ.) https://doi.org/10.14341/probl11607
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