The state of the hypothalamic-pituitary area by magnetic resonance images in patients with congenital somatotropic deficiency

Basing on the results of complex examination of 120 patients (53 children and 67 adults), hypothalamic-pituitary structures in congenital growth hormone (GH) deficiency in different age periods were analysed. Isolated growth hormone ing deficiency (1GHD) was diagnosed in 34,2%> of cases (25 children and 16 adults), the diagnosis of multiple adenohypophyseal hormone deficiency (MAHD) was made in 65,8% of patients (52 children and 81 adults). Organic lesions of hypothalamic-pituitary system were revealed in 91,7%> of patients. On MR images 3 main anomalies in the hypothalamic-pituitary region could be detected: pituitary hypoplasia (28,4%>), empty sella turcica (22,5%o) and triad of lesions including ectopia of the neurohypophysis in combination with hypoplasia of the adenohypophysis, and crus hypoplasia or aplasia (40,8%o). In children pituitary hypoplasia in combination with hypoplasia of the hypophysial crus, and ectopia of the neurohypophysis, in adults - pituitary hypoplasia were observed more frequently. In IGHD the rate of different abnormalities of pituitary development did not depend on age. In MAHD adults had more tuguently pituitary hypoplasia MAHD children - the triad of lesions (p < 0,05). In children with pituitary hypoplasia the hypophysis sizes in IGHD were larger than in MAHD (p < 0,02). In pituitary hypoplasia hypophysis sizes did not differ significantly in children and adults.

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