Diabetogenic viruses and histocompatibility system for insulin-dependent diabetes mellitus
https://doi.org/10.14341/probl11642
Abstract
Forty-six patients (25 men and 21 women) with newly diagnosed insulin-dependent diabetes (IDDM) aged 27.2 + 2.7 years were examined. HLA phenotype and titers of antibodies to epidemic parotitis and Coxsakie viruses were assessed. The incidence of HLA DR3, DR4, DQ2, and DQ3 was significantly increased in IDDM patients. No persuasive data on relationship between IDDM manifestation and parotitis were obtained. Diagnostically significant titers of antibodies to Coxsakie viruses were detected in diabetics more often in normal subjects. A close association between high titers of anti-Coxsakie antibodies and specific HLA antigens carriership was revealed. Vaccination of immunological marker carriers is proposed for primary prevention of IDDM.
About the Authors
B. L. RasovskyUral State Medical Academy
Russian Federation
T. I. Severina
Ural State Medical Academy
Russian Federation
N. Ya. Venediktova
Ural State Medical Academy
Russian Federation
L. G. Akhmedyanova
Ural State Medical Academy
Russian Federation
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Review
For citations:
Rasovsky B.L., Severina T.I., Venediktova N.Ya., Akhmedyanova L.G. Diabetogenic viruses and histocompatibility system for insulin-dependent diabetes mellitus. Problems of Endocrinology. 1998;44(5):8-10. (In Russ.) https://doi.org/10.14341/probl11642
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