The effect of chronic administration of neuropeptide Y on the state of B and a-cells of islets of Langerhans in intact and diabetic rats
https://doi.org/10.14341/probl11747
Abstract
The effect of neuropeptide Y (NPY) on the pancreatic endocrine function is studied. NPY was injected to intact and diabetic rats for 10 days intracerebroventricularly (i.c.v.) in a dose of 10 ng or intraperitoneally (i.p.) in a dose of 2.5 pg daily. In intact animals, NPY caused an increase in insulin content in the islets, more pronounced after i.c.v. injection. The content of glucagon in а-cells increased after i.p. injection and decreased after i.c.v. injection. In diabetic animals, NPY inhibited the destruction of P-cells and increased the content of insulin in the islets, which was more pronounced after i.c.v. injection. The count of ck-cells in the islets dropped to the control level, while the level of glucagon remained decreased (more so after p. injection). The content of insulin in the blood increased and level of glycaemia decreased. The effects of NPY upon its peripheral administration may be explained by direct action on aand P-cells and upon central administration by modulation of hypothalamic hormone secretion and function of dorsal component of vagus nerve.
About the Authors
Yu. M. KolesnikZaporizhzhya Medical University
Ukraine
A. V. Abramov
Zaporizhzhya Medical University
Ukraine
A. V. Trailin
Zaporizhzhya Medical University
Ukraine
S. D. Trezhetsky
Zaporizhzhya Medical University
Ukraine
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Review
For citations:
Kolesnik Yu.M., Abramov A.V., Trailin A.V., Trezhetsky S.D. The effect of chronic administration of neuropeptide Y on the state of B and a-cells of islets of Langerhans in intact and diabetic rats. Problems of Endocrinology. 1999;45(2):42-45. (In Russ.) https://doi.org/10.14341/probl11747
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