Altered lipid peroxidation and antioxidative plasma activity in patients with severe diffuse toxic goiter
https://doi.org/10.14341/probl11763
Abstract
Lipid peroxidation (LPO) and antioxidative plasma activity (APA) were examined in 96 female patients with severe diffuse toxic goiter (DTG, Graves "disease) whose age was 20 to 40years and in a control group of healthy individuals, matched by age. The patients with DTG were found to have enhanced LPO and APA (p < 0.05). There was a correlation between the degree of impaired APA and the incidence of some symptoms of DTG, primarily the signs of cardiovascular lesion. Clear relationships were found between the duration of DTG and the status of LPO and APA. All the patients were divided into 3 groups. In addition to the conventional therapy, trimethasidine, 60 mg/day, was given to Group 1 patients (n = 32) for a month. Group 2patients (n = 34) took a-tocopherol for a month. Group 3 patients (n - 30) received the routine thyrostatic therapy with mercaptoimidazole drugs. The use of drugs with antioxidative mechanism of action was found to result in the normalization of the levels of LPO products and APA in patients with DTG and to ensure earlier disappearance of the clinical signs of cardiovascular lesion than in the controls. Trimethasidine showed an earlier effect (on the average, by 3-4 weeks of therapy) than did a-tocopherol.
About the Authors
T. I. RodionovaNorthern State Medical University
Russian Federation
M. A. Kostenko
Northern State Medical University
Russian Federation
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Review
For citations:
Rodionova T.I., Kostenko M.A. Altered lipid peroxidation and antioxidative plasma activity in patients with severe diffuse toxic goiter. Problems of Endocrinology. 2003;49(5):42-45. (In Russ.) https://doi.org/10.14341/probl11763
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