Immunogenetic characteristics of diabetic microangiopathies

Abstract

lmmunogenetic studies were carried out in 103 diabetics with type I condition (40 men and 63 women aged 37.1+3.2 years) with disease standing of 7.6±2>3 years. Nonproliferative diabetic retinopathy was detected in 78 (75.7%)) and staring diabetic nephropathy in 88(85.4%)). The incidence of DR4, DR8, and DQ2 antigens is increased and that of Cw6 and DQ1 antigens decreased in diabetic retinopathy. В16, DR3, DR4, and DQ3 antigens predominated in diabetic nephropathy, while Cw6 and DQ7antigens were rarely detected. DR4 and DQ3 were the most incident in the patients with a combination of diabetic retinopathy and diabetic nephropathy (67.2%o of all cases). There were no notable differences in the spectrum of HLA antigens in the groups with diabetic retinopathy and diabetic nephropathy, which agrees with the reno-retinal syndrome concept. Afunctional status-metric model of individual recognition of the diabetic reno-retinal syndrome is created. A special register of patients with type I diabetes carrying immunogenetic markers of diabetic microangiopathies is proposed to be created for more stringent metabolic control and early preventive measures aimed at delay of microvascular complications.