Evaluation of the effectiveness of treatment with thyroxine and iodotyrox drugs in patients with diffuse non-toxic goiter in Moscow

The efficiency of therapy with a combined thyroxin-iodine drug and monotherapy with thyroxin was compared in patients with diffuse nontoxic goiter (DNG), and the effect of iodine intake was evaluated. The study was carried out in an outpatient setting by the double blind method in 46 women aged 18-50 years with DNG: 22 were treated by the combined drug (TI) containing 100 pg L-thyroxin and 100 pg potassium iodide per tablet (lodthyrox, Merck KGaA) and 24 were treated by thyroxin (T) in a dose of 100 pg (Euthyrox, Merck KGaA). The treatment was administeredfor 1 year. A year after this treatment, 15 women were treated with iodinated oil (IO) (lipidol capsules, Guerbet) containing 380 mg iodine. Thyroid volume, concentrations of intrathyroid stable iodine (ISI), pituitary thyrotropic hormone, free triiodothyronin and thyroxin, and antibodies to thyroglobulin and thyroid peroxidase in the blood were evaluated in all women before and during treatment.

Therapy with T and TI equally decreased the size of the thyroid in DNG. ISI concentration decreased during TI treatment less than during monotherapy. Thyroid volume increased to the pre-treatment size 12 months after therapy with T or TI was discontinued, while ISI concentration remained lowered. Administration of IO led to a decrease in the thyroid size, less pronounced than during T or TI treatment, and to an increase in ISI concentration.

thyroxine, iodirox, diffuse non-toxic goiter

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