Lipid peroxidation and a-tocopherol in patients with diffuse toxic goiter

Abstract

Plasma and erythrocyte concentrations of lipid acyl hydroperoxides, malonic dialdehyde (MDA), and a-tocopherol were measured in 45patients with diffuse toxic goiter (DTG) before and after thyrostatic therapy and in 26 of these patients 3—6 months after subtotal resection of the thyroid in a state of euthyrosis. The initial link in lipid peroxidation (LPO) was activated in erythrocytes and plasma in hyperthyrosis, while toxic LPO product MDA accumulated only in the plasma. The level of one ofpotent antioxidants a-tocopherol was decreased at all stages of examination in erythrocytes, while in the plasma it was decreased only before therapy. Estimation of the Horvitt index and LPO-antioxidant defense conjugation index (a-tocopherol requirement, content, or insufficiency) in the plasma and erythrocytes showed decreased content of vitamin E in tissues of patients with DTG, which recommends antioxidant therapy to DTG patients.