Rat uterus hormonal sensitivity after chemical desympathization
https://doi.org/10.14341/probl11971
Abstract
Currently, there is no convincing evidence of a significant role of female sex steroids in the genesis of node growth in uterine fibroids in women, since in many cases with this disease the hormonal status remains unchanged. It is not possible to explain this phenomenon with an increase in the concentration of estradiol receptors (E2) in fibromatous nodes, which could provide an increase in sensitivity to this hormone, which stimulates growth processes in the uterus. Previously, we found an increased content of receptors only in those nodes that consist mainly of myocytes (fibroids). In nodes, consisting mainly of connective tissue elements (fibromas), the concentration of E2 receptors was, on the contrary, reduced. It may be thought that an increase in the sensitivity of fibromyoma cells to estrogens is associated with the progressive denervation of the growing node. The present study was undertaken to test this hypothesis, given the fact that the question of the interaction of catecholamines (CA) and sex steroids at the level of target organs has been relatively little studied to date.
About the Authors
Ye. V. Sekretareva
Institute of physiology named after I. P. Pavlov RAS
Russian Federation
Russian Federation
F. I. Proimina
Institute of physiology named after I. P. Pavlov RAS
Russian Federation
Russian Federation
N. I. Flerova
Institute of physiology named after I. P. Pavlov RAS
Russian Federation
Russian Federation
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Review
For citations:
Sekretareva Ye.V., Proimina F.I., Flerova N.I. Rat uterus hormonal sensitivity after chemical desympathization. Problems of Endocrinology. 1993;39(2):37-39. (In Russ.) https://doi.org/10.14341/probl11971
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