Intestinal iransport of vitamin D3 and its metabolism in the liver of rats with alloxan-induced diabetes
https://doi.org/10.14341/probl11974
Abstract
Vitamin D3 intestinal transport and liver metabolism were studied in rats with alloxan-induced diabetes. The condition was induced by alloxan injection in a dose of 40 mg/kg b. m. Diabetes development was monitored by blood serum glucose measurements, carried out for 30 days. [3H]-cholecalciferol absorption in the rat intestine was found inhibited in the diabetic animals as against the reference animals, which fact results in disordered entry of vitamin D3 to the body. [3H]-cholecalciferol absorption by the liver is reduced in the examined condition, and the time of its metabolism is increased more than threefold as against the reference animals. The share of vitamin D3 hydroxylation by the liver of diabetic rats is also significantly reduced. The described disorders are responsible, among other things, for the reduction of the levels of vitamin D3 active metabolites in the blood serum of rats with experimental diabetes
About the Authors
L. I. Apukhovskaya
Institute of biochemistry of the Academy of Sciences of Ukraine
Ukraine
Ukraine
M. V. Stefanov
Institute of biochemistry of the Academy of Sciences of Ukraine
Ukraine
Ukraine
L. V. Antonenko
Institute of biochemistry of the Academy of Sciences of Ukraine
Ukraine
Ukraine
L. I. Omelchenko
Institute of biochemistry of the Academy of Sciences of Ukraine
Ukraine
Ukraine
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Review
For citations:
Apukhovskaya L.I., Stefanov M.V., Antonenko L.V., Omelchenko L.I. Intestinal iransport of vitamin D3 and its metabolism in the liver of rats with alloxan-induced diabetes. Problems of Endocrinology. 1993;39(2):43-46. (In Russ.) https://doi.org/10.14341/probl11974
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