Gestagens and heart
https://doi.org/10.14341/probl12030
Abstract
The use of gestagen hormones (progestogens, progestogens, progestins) in modern medicine is mainly based on their effect on the reproductive sphere of the female body, including menstrual dysfunction (luteal phase of the cycle), contraception, pregnancy support, correction of hormonal homeostasis during menopause, antitumor activity in some hormone-dependent oncological diseases. The presence of antiandrogenic properties in a number of progestogens (C21-derivatives), which have found application as antihormonal therapy for certain endocrine diseases in women (hirsutism) and for malignant neoplasms of the male genital organs, should be highlighted. The variety of influences exerted by natural gestagen hormones and their synthetic analogs on the human body also encompasses a change in their action of cardiovascular activity. Moreover, according to some authors, the heart and large vessels are the targets of the action of gestagens. It is assumed that a change in the hormonal characteristics of the female body during the normal menstrual cycle does not cause existing changes in the reactivity of the cardiovascular system. However, fluctuations in cardioactive and vasoactive parameters can be observed even with physiological differences in the level of endogenous progestogens and estrogens (menstrual cycle, pregnancy, menopause). The greatest severity of maladaptation phenomena in cardiac activity (according to the mathematical analysis of cardiointervalograms) was revealed precisely at peak concentrations of female sex hormones within the estrous cycle - in the phases of proestrus and metaestrus. During menopause and postmenopause, when the cardioprotective effect of endogenous estrogens and gestagens is significantly reduced, a violation of cardiac and vasomotor activity can be detected, often requiring hormone replacement therapy with estrogen-gestagen drugs.
About the Authors
A. N. Karachentsev
Russian State Medical University
Russian Federation
Russian Federation
P. V. Sergeev
Russian State Medical University
Russian Federation
Russian Federation
A. I. Matyushin
Russian State Medical University
Russian Federation
Russian Federation
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For citations:
Karachentsev A.N., Sergeev P.V., Matyushin A.I. Gestagens and heart. Problems of Endocrinology. 1996;42(2):42-45. (In Russ.) https://doi.org/10.14341/probl12030
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