Study of human thyroglobulin gene polymorphism
https://doi.org/10.14341/probl12089
Abstract
The main goal of this work was to conduct a population genetic analysis of RFLP detected in the TG gene and to develop a system of molecular genetic studies of hereditary thyroid diseases associated with polynucleotide rearrangements in the structure of TG. A population genetic analysis of RFLP detected in the TG gene was carried out. When splitting blood samples of healthy Tashkent residents with EcoRV and Taql restriction enzymes, 2 pairs of alternative variants of normal RFLP were detected - 13.8 or 8.5 and 5.8 or 6.2 bp respectively. In order to detect RFLP in the TG gene for congenital hypothyroidism, DNA samples from 2 families (mother, father, daughter) with a clinical diagnosis of congenital hypothyroidism were analyzed and the same variants of RFLP found in healthy individuals.
About the Authors
D. A. Kadyrova
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
Uzbekistan
B. A. Atakhanova
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
Uzbekistan
M. L. Rakhimova
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
Uzbekistan
G. D. Umarova
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
Uzbekistan
Ya. Kh. Turakulov
Institute of Biochemistry, Academy of Sciences of the Republic of Uzbekistan
Uzbekistan
Uzbekistan
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Review
For citations:
Kadyrova D.A., Atakhanova B.A., Rakhimova M.L., Umarova G.D., Turakulov Ya.Kh. Study of human thyroglobulin gene polymorphism. Problems of Endocrinology. 1996;42(5):34-36. (In Russ.) https://doi.org/10.14341/probl12089
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