Antioxidants (alpha-tocoferol acetate) in therapy of diabetes mellitus
https://doi.org/10.14341/probl11942
Abstract
The authors have examined the time course of lipid peroxidation processes and the levels of total lipids in red cell membranes and blood plasma of diabetics administered alpha-tocoferol acetate. Patients with medium-severe diabetes of the first and second types were divided into 2 groups. Group 1 patients were administered only traditional sugar-reducing treatment, in Group 2 alpha-tocoferol acetate in a daily dose 300 mg was added to such therapy. Similar examinations were carried out in both the groups before and after the treatment. Lipid peroxidation levels and the content of total lipids were found significantly increased in the cellular membranes and blood plasma of Group 2 patients, whereas in Group 1 no changes of this kind were detected. Therapy with alpha-tocoferol acetate normalized lipid peroxidation processes in the red cell membranes and the total lipid content in the blood plasma reduced the blood plasma level of lipid peroxidation products and the content of total lipids in red cell membranes. These results permit a conclusion on the favorable effect of alpha-tocoferol acetate on blood plasma lipid peroxidation and total lipid levels in diabetics.
About the Authors
N. S. KuznetsovCrimean medical Institute
Russian Federation
Abdel Mohson Abulela
Crimean medical Institute
Russian Federation
V. N. Neskoromny
Crimean medical Institute
Russian Federation
References
1. Бурлакова Е. Б., Молочкина Е. М, Пальмина Н. П. // Вопр. мед. химии.— 1976.— Т. 22. № 4.— С. 541—546.
2. Воскресенский О. И. // Липиды в организме животных и человека.— М., 1974.— С. 36—45.
3. Гаврилов В. Б., Мишкорудная М. Л. // Лаб. дело.— 1983 — 3. - — . 33—36.
4. Ефимов А. С. // Пробл. эндокринол.— 1985.— № 5.— С. 55—59.
5. Ефимов А. С., Науменко В. Г. // Пробл. эндокринол.— № 1.— С. 6-9.
6. Иванов В. В., Васенева И. В, Удинцев Н. А. // Пробл. эндокринол.—1984 —№ 1 .— С. 70—73.
7. Козлов Ю. П. // Липидный биосинтез. структура превращения и функция.— М.. 1977.— С. 80—93.
8. Колб В. Г., Камышников В. С. // Клиническая биохимия.— Минск. 1976.— С. 152—154.
9. Обухова Л. К. // Успехи химии.— 1975.— Т. 44. № 10.— С. 1914—1925.
10. Сербинова Т. А. Получение свободной от гемоглобина мембраны эритроцитов и изменение ее структуры при повреждающих воздействиях и хранении крови: Авгореф. дис. ... канд. мед. наук.— М.. 1980.
11. Старосельцева Л. К., Косилова Е. С., Смуркова Т. Ф. и др. // Пробл. эндокринн— 1986.— № 1.— С. 19—22.
12. Сюрин А. А., Кулагин Ю. И. // Сов. мед.— 1987.— № 11.— С. 14—16.
Review
For citations:
Kuznetsov N.S., Abulela A.M., Neskoromny V.N. Antioxidants (alpha-tocoferol acetate) in therapy of diabetes mellitus. Problems of Endocrinology. 1993;39(2):9-11. (In Russ.) https://doi.org/10.14341/probl11942
Views:
1481
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0).
Email this article 
.jpg){kind=logo}
