The article is devoted to the study of the autoimmune latent diabetes in adults.

The article is devoted to the study of the cytokines and their implication in the pathogenesis of diabetic retinopathy.

The article is devoted to the review of the disputable problems in the treatment of differential thyroid cancer.

The article is devoted to the study of free cortisol in the saliva for the evaluation of adrenal function.

The article is devoted to the study of the genetics of isolated of hypogonadotropic hypogonadism.

Sixty-two patients aged 6.5 to 20 years (median 13.4 years) were examined 4.2 years after termination of treatment for medullob-lastoma. All the patients underwent craniospinal irradiation in a dose of 35 and 55 Gy to the area of the posterior cranial fossa. After radiotherapy (RT), 56 patients received polychemotherapy (PCT), in 40 patients of them PCT was performed by the M-2000 protocol in the maintenance and cycle modes. Thirty-seven (79%) out of 47 children were found to have growth hormone deficiency; 19 out of the 62 patients had growth retardation with the unproportionalfy short upper segment of the body. No thyroid and gonadal lesions were revealed in 6 patients receiving RT alone. In patients having RT and PCT, primary hypothyroidism developed In 32 (57%) of the 56 cases; gonadal lesion did in 19 out of 20 females and 12 of 24 males. Five children were observed to have clinical and hormonal signs of secondary adrenal Insuf- '35 ПРОБЛЕМЫ ЭНДОКРИНОЛОГИИ, 2008. Т. 54, № 2. ficiency. Bone mineral density (BMD) in the whole group was -1.7 SD (standard deviation) and -2.4 SD in the lumbar spine; 32 (55%) out of 58 patients developed spinal scoliosis. The patients receiving maintenance PCT by the M-2000 protocol had a more pronounced weight loss, growth retardation, and spinal BMD decrease than those having PCT as cycles. Furthermore, primary hy-pogonadism more frequently developed after maintenance PCT than after cyclic PCT.

Hyperandrogenism is a commonest endocrine disorder in women of reproductive age and a cause of many metabolic diseases. The purpose of this study was to measure the blood levels of androgens in women with hirsutism (Ferriman-Gallwey scale > 8 scores) and to reveal the most informative marker of hyperandrogenism in hirsutism. A hundred forty-nine women aged 18-35 years who complained about hirsutism were examined. The women with hirsitism (Ferriman-Gallwey scale > 8 scores) were observed to have statistically significantly elevated serum levels of total testosterone, dehydroepiandrosterone sulfate, and sex hormone-binding globulin and the high free androgen index (p < 0.001). The increased free androgen index (54.8%) was more frequently detected in hirsutism. This study showed that hirsutism was doubtlessly associated with the elevated serum content of androgens; however, even 34.4% of the females had normal blood leveb of androgens.

The paper presents the results of surgical treatment in 120 patients living in an endemic area, who have been operated on for benign thyroid diseases. The toxic forms of goiter amounted to 85%. A long history of the disease, the enlarged thyroid, and a large number of patients with complicated forms of the disease were noted. There was a preponderance of maximum subtotal resections (with less than 1 g of the parenchyma being left) and thyroidectomies in the structure of operations. The incidence of postoperative complications was 15.8%. Transient postoperative bilateral laryngeal paresis and transient hypocalcemia were observed in 5 (4.2%) and 10 (8.3%) cases, respectively. The detected features of the course of the diseases and transient postoperative complications allow thyroidectomy and subtotal thyroid resection, with less than 1 g of the parenchyma being left, to be regarded as the methods of choice in the surgical treatment of benign diseases of the thyroid in its bilateral lesion.